Aβ Behavior on Neuronal Membranes: Aggregation and Toxicities
نویسندگان
چکیده
1Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522, Japan 2Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2M), Université de la Méditerranée Aix-Marseille II et Université Paul Cézanne Aix-Marseille III, CNRS UMR 6231, INRA USC 2027, 13284 Marseille Cedex 07, France 3Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, TMDT 4-305, 101 College Street, Toronto, ON, Canada M5G 1L7 4Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, 4025 Basel, Switzerland
منابع مشابه
Highly potent intracellular membrane-associated Aβ seeds
An early event in Alzheimer's disease (AD) pathogenesis is the formation of extracellular aggregates of amyloid-β peptide (Aβ), thought to be initiated by a prion-like seeding mechanism. However, the molecular nature and location of the Aβ seeds remain rather elusive. Active Aβ seeds are found in crude homogenates of amyloid-laden brains and in the soluble fraction thereof. To analyze the seedi...
متن کاملModeling the Aggregation Propensity and Toxicity of Amyloid-β Variants.
Protein aggregation is a hallmark of many neurodegenerative disorders. Alzheimer's disease (AD) is directly linked to deposits of amyloid-β (Aβ) derived from the amyloid-β protein precursor (AβPP), and multiple experimental studies have investigated the aggregation behavior of these amyloids. The present paper reports modeling of the aggregation propensities and cell toxicities of genetic varia...
متن کاملStability of Transmembrane Amyloid β-Peptide and Membrane Integrity Tested by Molecular Modeling of Site-Specific Aβ42 Mutations
Interactions of the amyloid β-protein (Aβ) with neuronal cell membranes, leading to the disruption of membrane integrity, are considered to play a key role in the development of Alzheimer's disease. Natural mutations in Aβ42, such as the Arctic mutation (E22G) have been shown to increase Aβ42 aggregation and neurotoxicity, leading to the early-onset of Alzheimer's disease. A correlation between...
متن کاملLipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes
Lipid rafts are membrane microdomains, enriched in cholesterol and sphingolipids, into which specific subsets of proteins and lipids partition, creating cell-signalling platforms that are vital for neuronal functions. Lipid rafts play at least three crucial roles in Alzheimer's Disease (AD), namely, in promoting the generation of the amyloid-β (Aβ) peptide, facilitating its aggregation upon neu...
متن کاملMembrane-Protein Interactions Are Key to Understanding Amyloid Formation.
Formation S by the appreciation that protein aggregation, leading to amyloid fibril formation, is linked to a growing list of diseases, there has been intense effort to understand the factors that trigger association between peptides. This vastly complex field has attracted a variety of approaches ranging from mutational studies at the genetic level to characterization of events at the molecula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011